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Home » Science » Biology » Immunology » Cytokines Cytokines
A large class of glycoproteins similar to lymphokines but produced by non-lymphocytic cells such as normal macrophages, fibroblasts, keratinocytes and a variety of transformed cell lines. The most well known cytokines are the interferon (IFN) and interleukins (IL-1, IL-6). They were discovered through their role in regulating immunological and inflammatory and repair processes. However, they also regulate normal cell growth and differentiation.
Cytokines are analagous to hormones in their intercellular regulatory functions at very low concentrations, but are not produced by glands. [see Endocrinology]
Hence, some discovered by their action, rather than their chemical structure, have been named Growth_Factors, and yet these function throughout life, eg. to stimulate the endothelial cells to express 'selectins' on the internal surfaces of blood vessels, causing leukocytes to adhere, then be removed from circulation between endothelial cells.
Sub-Categories:
| International Cytokine Society - Society affairs, members and application details, conferences, downloadable PDF newsletters, links to journals and other resources. Also discussion group, including archive to 1997, and contact list for postdoctoral posts worldwide.
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| | Research Diagnostics Inc. - Offers, for in vitro research use only, recombinant growth factors, cytokines, chemokines and in some case ELISA kits and receptors, including soluble free fraction VEGF-receptor kit, from Flanders, NJ.
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| | Cytokine Webfacts - Subscription only compendium on cytokines and their receptors, consists of the entire content of the Cytokine FactsBook, published by Academic Press, Elsevier Science.
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| | Cytokines Online Pathfinder Encyclopedia - COPE, claiming over 10,000 entries, over 19,000 references on cytokine research, extensive hyperlinks, with tables, formulae, graphics, and integrated sub-dictionaries on related disciplines. Includes profile of author Prof. Horst Ibelgaufts.
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| | Molecular Mediators, Cytokines - Eight topic lectures covering cytokines, their first description, features, philosophy, comparison with hormones, chemokines and the classes of receptor families. Part of the pathology course by Alexander G. Izaguirre at University of Medicine and Dentistry of New Jersey.
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| | Cytokines Web - Structure and function of cytokines and their receptors, and their potential therapeutic uses, in treatment of cancer and AIDS, provided by the medical university, Beijing, China.
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| | Growth Factors and Cytokines - Introduction to growth factors and cytokines maintained by Michael W. King at the School of Medicine, Indiana State University, Terre Haute, IN.
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| | SBH Sciences - Promoting collaboration and outsourcing to develop cell culture processes, including proliferation and neutralization bioassays, using their cytokines and growth factors in cell culture media, from manufacturer at Natick, MA.
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| | Cytokine - Subscription and submission invitation for articles on study and applications of interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, and putative cytokines in the official journal of the International Cytokine Society, published by Academic Press.
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| | Cytokine Family Database - A collection of EST (Expressed Sequence Tag) records of cytokines deposited in the NCBI GenBank.
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| | Cytokine Signaling Pathway Database - Contains information on signaling pathways of cytokines for biomedical researchers.
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| | ICI Cytokine Data Collection - Information on main cytokines, pictures regarding cytokine receptor classes, links to signal pathways, internet resources, and slide show about signalling pathways inside the cell, maintained by Institute of Clinical Immunology, FSU Jena, Germany.
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| | Cytokine Reference - A compendium of cytokines and other mediators of host defense. Cytokines structure and function description, gene regulation, in vivo and in vitro activities, diagnostic and therapeutic utilities as well as cytokine classification by family, receptor, name, disease and cell type.
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| | Cytokine Interest Group - Forum for the interaction of scientists with a common interest in the immunology, molecular biology and physiology of cytokines, information on mini-symposia by NIH-area scientists dealing with multidisciplinary aspects of cytokine research, as well as membership open to all. Maintained by National Institute of Health, Bethesda, Maryland.
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| | Structural Biology in the Walter Lab - Studies of the alpha helical cytokine family Interferon-gamma, interferon-alpha, and interleukin-10, their receptors, intracellular signaling molecules with emphasis on understanding the structural basis of molecular recognition events that subsequently lead to cellular signal transduction, maintained by Mark R. Walter laboratory at the University of Alabama at Birmingham.
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| | PRGF. Plasma Rich in Growth Factors - Technique for bone and tissue regeneration, conceived and developed by BTI Biotechnology Institute. Some of his therapeutical applications are oral, maxillofacial, periodontal surgery and dental implants.
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| | Muscle and immune proteins - Overview of sarcopenia and potentialities of physical exercise as an prevention method of immunosenescence, correlation between the muscle mass and TNF-alpha:IL-6 ratio.
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| | R & D Systems - Cytokine Facts - Cytokines mini-reviews, their applications, cytokine facts and literature, maintained by R&D Systems company.
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| | Cytokines in Allergic Disease - Overview of main cytokines engaged in allergic responses and their therapeutic potential in allergic diseases. Maintained by Medical Education Information Center, University of Texas.
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| | The International Society for Interferon and Cytokine Research - The cytokine-interferon open forum, downloadable PDF newsletters, links to conferences, meetings, related websites and journals as well as society matters and membership details along with application forms.
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| | Cytokines - Overview of cytokines, their properties, activities and receptors. Part of immunology course offered by the Department of Veterinary Science and Microbiology at the University of Arizona, USA.
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| | Trophic factors - Contains information on neurotrophins, cytokines, growth factors - their main features, receptors and receptor subunits, as well as trophic factor related disorders. Maintained by the Neuromuscular Disease Centre at the Washington University, St.Louis, MO, USA.
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| | Conference on Local Vascular and Inflammatory Mediators - Exploring the future directions in unraveling the roles of local vascular and inflammatory mediators in health and disease and their potential as targets in drug therapy. The meeting to be held in Lund, Sweden on May 26-28, 2005.
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| | T-Helper Cells & Cytokines In Multiple Sclerosis - Four abstracts covering the role of cytokines and T-helper cells in multiple sclerosis.
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| | Cytokines and psychiatry - Abstract of review of recent developments in cytokine biology that are relevant to clinical psychiatry. The role of cytokines in various brain activities and pathophysiology of specific psychiatric disorders.
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| | Hormones and Cytokines - Overview of regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action.
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| | Cytokines at Dalhousie University - Review of main cytokines and their principle activities. Maintained by Faculty of Medicine, Dalhousie University, Canada.
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